Mice Model may be useful in studying Presbylaryngis

Published in August 2007 in the Annals of Otology Rhinology & Laryngology, Abdelkafy et al. address "Age-related changes in the murine larynx: initial validation of a mouse model."

The authors stained laryngeal tissue from 9 aged and 9 young mice to validate a mouse model for the aging larynx. They stained the larynges with Alcian blue to determine the hyaluronic acid content, trichrome stain to determine the collagen content, and immunohistochemical stain for alpha smooth muscle actin to determine the myofibroblast content. Morphometric measurements were performed for muscle area, muscle thickness, and muscle fiber diameter. Statistically significant differences in the density measurements of hyaluronic acid and collagen reflected decreased hyaluronic acid and increased collagen content in the aging larynx. Alpha smooth muscle actin-labeled myofibroblasts were only evident in the aged larynges. No statistically significant differences were found in the morphometric measurements. In conclusion aged mice may make a practical model for the age-related changes in the vocal folds that can be used further in studies aiming to correct these changes.

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